SIN3 Complex Regulates Gene Expression and DNA Replication (P22253)

Target Name: SIN3 complex

NCBI ID: P22253

Other Name(s): Histone deacetylase complex | SIN3-repressing complex.

SIN3 Complex Regulates Gene Expression and DNA Replication

SIN3 complex, also known as the histone deacetylase (HDAC) complex, is a protein complex that plays a critical role in the regulation of gene expression and DNA replication in the nucleus of the cell. The SIN3 complex is composed of three subunits: SIN3A, SIN3B, and SIN3C. Each subunit of the SIN3 complex has distinct functions, and the complex plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and DNA replication.

The SIN3 complex is responsible for the deacetylation of the histones, which are small proteins that play a structural role in organizing DNA in the nucleus. The histones are highly acidic, and when they are acetylated, they become positively charged and can interact with other proteins . The SIN3 complex helps to regulate the levels of acetylation on the histones, which in turn affects the stability of the chromatin complex and the accessibility of the DNA for various enzymes.

The SIN3 complex is a highly conserved protein complex that is found in all eukaryotic cells. It is expressed in a variety of tissues and organs, including brain, muscle, heart, and reproductive organs. The SIN3 complex is also involved in the regulation of cellular processes that are critical for the development and maintenance of tissues, such as cell proliferation, apoptosis, and stem cell maintenance.

SIN3 complex has been implicated in a wide range of cellular processes, including the regulation of cell growth, apoptosis, and stem cell maintenance. Studies have shown that the SIN3 complex plays a critical role in the regulation of cell cycle progression, and that it is involved in the formation of replication forks and the metaphase of cell division.

In addition to its role in cell cycle progression, the SIN3 complex is also involved in the regulation of cellular signaling pathways. It has been shown to be involved in a variety of signaling pathways, including the regulation of DNA replication, cell growth, and apoptosis . The SIN3 complex has also been shown to play a critical role in the regulation of stem cell maintenance and the development of tissues.

The SIN3 complex is a protein complex that plays a critical role in the regulation of gene expression and DNA replication in the nucleus of the cell. Its functions include the regulation of cell growth, apoptosis, and stem cell maintenance. The SIN3 complex is a potential drug target and could be a useful biomarker for the diagnosis and treatment of various diseases.

Protein Name: SIN3 Complex

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